Ophthalmic ointment contains 30 mg of aciclovir in white soft paraffin base aciclovir 3 per cent. Application for the inclusion of aciclovir eye ointment in the who list. While effective, they tended to have low bioavailability and measurable local cellular toxicity due to their nonselective mode of action. Acyclovir ointment fda prescribing information, side. If this happens, wash right away with plenty of water. Use this ointment as soon as possible after you notice the beginning of a herpes sore pain, burning, blisters, or itching. Aciclovir the active ingredient in zovirax ophthalmic ointment belongs to a group of. To assess whether antiviral treatment can prevent recurrences of ocular hsv disease, we conducted a.
Consumer information about the medication acyclovir ointment topical zovirax, includes side effects, drug interactions, recommended dosages, and storage information. Zovirax ointment uses include the treatment of genital herpes and cold sores. Reconstitute 500mg or 1g vial with 10 ml or 20 ml, respectively, of sterile water for injection. Take missed doses as soon as possible but not just before next dose is due. Acyclovir ointment 5% is a formulation for topical administration. Formulation and evaluation of acyclovir ophthalmic inserts article pdf available in asian journal of pharmaceutical sciences 32. Acyclovir read all of this leaflet carefully before you start using. Oral acyclovir for herpes simplex virus eye disease. Each gram of zovirax ointment 5% contains 50 mg of acyclovir in a polyethylene glycol peg base. Use your finger to gently pull down the lower eyelid of your infected eye. Apply 1cm about 12 an inch of zovirax eye ointment to the inside of your lower eyelid. Acyclovir ophthalmic ointment avaclyr 3% treatment of acute herpetic keratitis dendritic ulcers apply 1 cm of ointment in the lower culdesac of the affected eye 5 times per day until. Wash your hands after applying zovirax eye ointment. Zovirax eye ointment is a registered trademark of the glaxosmithkline group.
Acyclovir ointment usp, 5% is contraindicated in patients who develop hypersensitivity to the components of the formulation. Manual searching included index medicus from 1960 through 1965 and. Pdf a validated stabilityindicating hplc assay method. Resistant strains have been isolated in vitroand in animals following treatment with aciclovir. Pdf formulation and evaluation of acyclovir ophthalmic. Clean and dry the affected areas before applying the medication. Why is it important for my child to take this medicine. Zovirax ophthalmic ointment acyclovir drug medicine. Zovirax eye ointment contains aciclovir 3% ww as the active ingredient. Avaclyr is a topical sterile ointment containing 3% acyclovir. Acyclovir ointment usp, 5% is a formulation for topical administration. Ointments and creams used in the pharmaceutical and cosmetics industry may contain solid particles andor emulsion droplets.
Acyclovir oral tablet is a prescription drug thats available as the brandname drug zovirax. Zovirax ophthalmic ointment is contraindicated in patients with a known hypersensitivity to aciclovir or valaciclovir, or any of the excipients listed in section 6. With the other hand, put a small ribbon of ointment into the pouch. Try to avoid the tip of the tube touching any part of your eye. Twenty nine published clinical trials with acyclovir acv ophthalmic. Read all of this leaflet carefully before you start using this. Acyclovir is a synthetic nucleoside analogue active against herpes viruses. Nda 202408 page 4 prescribing information for avaclyr.
Aciclovir eye ointment for herpes simplex infection this leaflet is about the use of aciclovir eye ointment for the treatment of infections caused by the varicella zoster virus or herpes simplex virus. Pdf on apr 14, 2012, milind baburao ubale and others published a validated stabilityindicating hplc assay method for acyclovir in bulk drug. Acyclovir is an antiviral drug, a synthetic nucleoside analogue, that has inhibitory activity interferes with viral replication against the herpes viruses, including herpes simplex 1 and 2. Zovirax ophthalmic ointment works by stopping the production of the herpes simplex virus. Generic drugs usually cost less than the brandname version. Zovirax ophthalmic ointment is used for the treatment of herpes simplex virus infections of the eye. Fiftyseven patients with hzo within 72 hours of the onset of rash received either topical acyclovir ointment or 800 mg oral acyclovir, both 5 times daily for 7 days, and were. Zovirax ophthalmic eye ointment acyclovir consumer medicine information name address what is in this leaflet this leaflet answers some common questions about zovirax ophthalmic. Aciclovir eye ointment for herpes simplex infection. Zovirax ophthalmic ointment is only suitable for use in the eye. Acyclovir should not be used more frequently or longer than prescribed.
Do not touch the tip of the bottle to your eye or anything else. If you forget to use aciclovir if you forget to use aciclovir, use it as soon as you remember. Do not use zovirax ophthalmic ointment if the packaging is torn or shows signs of tampering. Precautions and warnings with acyclovir ointment to be aware of prior to taking it include the fact that it is not intended to be used to treat herpes infections of the eye. Read all of this leaflet carefully before you start using this medicine because it contains important information for you. Zovirax eye ointment patient information leaflet pil. Capitals indicate lifethreatening, underlines indicate most frequent. Each gram of acyclovir ointment usp, 5% contains 50 mg of acyclovir in a polyethylene glycol peg base. Aciclovir eye ointment is for use in the eye, if you swallow any talk to your doctor or pharmacist. Begin using acyclovir as soon as symptoms of a herpes infection appear. What zovirax eye ointment is and what it is used for zovirax eye ointment contains a medicine called aciclovir.
Other preparations of this medicine may still be available. The recommended dosing regimen is to apply a 1 cm ribbon of ointment in the lower culdesac of the affected eye 5 times per day approximately every 3 hours while awake until the corneal ulcer heals and then a 1 cm ribbon 3 times per day for 7 days. Acyclovir acyclovir sodium dose, indications, adverse. Herpes simplex virus hsv is an important cause of corneal disease and visual loss. Aciclovir eye ointment for herpes simplex infection this leaflet is about the use of aciclovir eye ointment for the treatment of infections caused by the varicella zoster virus or.
Patientfamilyteaching instruct patient to take medication as directed for the full course of therapy. This information has been left on emc for reference purposes. A vast amount of practicerelated information is available to todays healthcare practitioner. Learn about the reported side effects, related class drugs, and how these medications will affect your daily lifestyle. Do not touch the tip of the bottle to your childs eye or anything else.
The pharmaceutical company has decided to discontinue this product. Acyclovir ointment, usp is a synthetic nucleoside analogue active against herpes viruses. Do not administer acyclovir injectable topically, im, subcut, po, or in the eye. While the drug is not a cure for these conditions, it can help symptoms heal faster by preventing the herpes. What zovirax eye ointment looks like and contents of the. During the toxicosis induced by thelarger doses of acyclovir, plasma levels of the drug. Zovirax is the brand name for acyclovir, a synthetic nucleoside analogue active against herpes viruses. Wash your hands with soap and water before and after using this medication. Acyclovir topical ointment 5pct drug medication dosage information. Your doctor may have prescribed zovirax ophthalmic ointment. However, if it is nearly time for your next application, skip the missed application. Patients should avoid wearing contact lenses when using zovirax ophthalmic ointment.
Avaclyr is used to treat acute herpetic keratitis dendritic ulcers in the eye in patients with herpes simplex hsv1 and hsv2 virus. Zovirax ophthalmic ointment does not get rid of the virus from your body. Acyclovir topical ointment 5pct drug medication dosage. Pdr drug summaries are concise pointofcare prescribing, dosing and administering information to help phsyicans more efficiently and accurately prescribe in their practice pdr s drug.
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